Selective target protein detection using a decorated nanopore into a microfluidic device

Single-molecule DNA detection using a novel SP1 protein nanopore.

SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candid...

Capture, Unfolding, and Detection of Individual tRNA Molecules Using a Nanopore Device

Transfer RNAs (tRNA) are the most common RNA molecules in cells and have critical roles as both translators of the genetic code and regulators of protein synthesis. As such, numerous methods have focused on studying tRNA abundance and regulation, with the most widely used methods being RNA-seq and microarrays. Though revolutionary to transcriptomics, these assays are limited by an inability to ...

Rapid Detection of Norovirus Using Paper - based 1 Microfluidic Device

Microfluidic Separation and Electrochemical Detection of Serotonin Using a Portable Lab-on-a-Chip Device

Using a lab-on-a-chip device, an analytical method was developed and validated for the quantitative determination of serotonin. Serotonin is a neurotransmitter that has a number of roles in biological processes. It is essential to be able to detect and quantify serotonin in different biological fluids because it can be used to evaluate and diagnose several disorders and diseases including depre...

Selective detection of NO2 and C2H5OH using a Co3O4-decorated ZnO nanowire network sensor.

The selective detection of two different gases, NO(2) and C(2)H(5)OH, has been achieved using a p-type Co(3)O(4)-decorated n-type ZnO nanowire (NW) network sensor. The gas selectivity was explained by the catalytic effect of nanocrystalline Co(3)O(4) and the extension of the electron depletion layer via the formation of p-n junctions.